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The substrains have phenotypic differences [ 3435 ], and some of the underlying genetic variations have been identified [ 3436 ]. The hybrid mice are heterozygous genetically and tend to serve as a background for some deleterious mutations. nackson

While the advantage of using a "standard" strain in research is apparent, interesting issues have been raised about the drawbacks of such a practice, see The Trouble With Black Chopra S et al backcrossed Vav1cre and CD11ccre mice with other floxed mice to generate conditional knockouts in leukocytes or dendritic cells, respectively [ 50 ]. This has included histone modifications during human parental-to-zygotic transition [ 51 ], the role of synaptotagmin-3 in endocytosis and synaptic strength [ 46 ], and cerebrospinal fluid influx during ischemia [ 3 ].

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